منابع مشابه
Obesity and Appetite Control
Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity. Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. The hypothalamus is a key region which possess...
متن کاملCan gut hormones control appetite and prevent obesity?
The current obesity epidemic is fuelled by the availability of highly palatable, calorie-dense food, and the low requirement for physical activity in our modern environment. If energy intake exceeds energy use, the excess calories are stored as body fat. Although the body has mechanisms that act to maintain body weight over time, they primarily defend against starvation and are less robust in p...
متن کاملAppetite Control: Does leptin lighten the problem of obesity?
Events of the past twelve months have had an explosive impact on the field of obesity research. This wave of excitement was triggered by a momentous announcement from Zhang et al. [1] in December 1994. The authors reported that they had identified the gene responsible for obesity in one of the most intensively studied genetic rodent models of the disorder, the ob/ob mouse, homozygous for a muta...
متن کاملAppetite regulation and seasonality: implications for obesity.
High circulating concentrations of leptin in obesity are associated with an apparent loss of its characteristic anorexic action within the hypothalamic region of the brain. Central insensitivity to leptin may therefore contribute to the aetiology of this disease, and an increased understanding of the underlying mechanisms will identify potential means of prevention and/or therapeutic targets. S...
متن کاملAppetite regulation: Shedding new light on obesity
New information illuminating the potential causes of obesity has been appearing rapidly, beginning with the cloning, by Friedman’s group, of the mouse obese (ob) gene, as reported in December 1994 [1]. Many reports on related topics and other molecular biological approaches to obesity have followed, particularly in the last several months. These reports help to form a picture that places regula...
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ژورنال
عنوان ژورنال: Experimental Diabetes Research
سال: 2012
ISSN: 1687-5214,1687-5303
DOI: 10.1155/2012/824305